Formulation and Evaluation of Orodispersible Tablets of Apremilast by Inclusion Complexation using β-Cyclodextrin

Abstract: Introduction: The present study was carried out to formulate and evaluate orodispersible tablets of Apremilast with a purpose providing better patient compliance geriatric, pediatric, impaired, travelling non-cooperative patients suffering from psoriasis. Such are in need fast easy swallowing drug delivery system. Materials Methods: Apremilast-β-cyclodextrin inclusion complex prepared by physical blending method principle increasing the solubility permeability drug. efficiency Apremilast: β-cyclodextrin ratios (1:1,1:2,1:3) were calculated it investigated that 1:2 ratio is highest. apremilast (F1 F9) simple cost effective direct compression technique using different concentrations super disintegrate croscarmellose sodium. Results: results pre-compression characteristics powder blends postcompression parameters studied showed satisfactory. Among all formulations studied, Formulation F6 less disintegration time percent cumulative release 98.7% so declared as an optimized formulation. Conclusion: Therefore, It can be concluded dissolution, absorption, therapeutic effect bioavailability significantly greater than those compared conventional treatment psoriasis cost-effective manner compliance. Key words: Psoriasis, Orodispersible Tablet, Inclusion Complexation, Apremilast-β cyclodextrin, Croscarmellose